In the fifth mission of the Dr. Aeon Strike Force, defeat all 12 optional AV/Monster/Hero-class opponents while traversing alternate realities. You must defeat all 12 in the same run.

First Ripple (Steel Canyon)

Don't use the portals. Instead, go all the way north to the launchpad. The enemies lined up on the launchpad will rush you when you attack the arch-villains, so clearing the launchpad first may be helpful. Defeat the optional arch-villains Arachn, Maestro, Nosferatu, and Protean in any order. Finally, defeat Emperor Requiem to automatically leave the ripple.

Second Ripple (Eden)

Don't drain the pustules. The enemies in the area will rush you when you attack the monsters, so clearing the area first may be helpful. Defeat the optional monsters Gale, Quill, Slate, and Tundra in any order. Finally, defeat Terra, the All-Mother to automatically leave the ripple.

Third Ripple (Portal Corp)

Defeat Apex and make a deal with PsiCurse in any order. Don't set the portal to return to Langston. Instead, set the portal to infiltrate Portal Corp. Enter and defeat Glacia and Infernia to thaw the portal to the Vanguard Compound. Defeat the optional heroes Hero 1 and Incandescent in any order.